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Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein
Product Name Pomalidomide-C5-amine HCl Synonyms Pomalidomide-4'-C5-amine HCl CAS Number 2375194-03-7 Related CAS 2093386-39-9 (free base) Molecular Formula C18H23ClN4O4 Molecular Weight 394
NCCOCCNC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Product Name Phthalimidinoglutarimide-5'-C3-O-PEG1-C2-amine HCl Synonyms CAS Number n/a Related CAS Molecular Formula C20H28ClN3O5 Molecular Weight 425
Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE Size:25mg Thalidomide-5-OH is the Thalidomide-based cereblonSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to
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