Azide-Hexanoyl-Val-Ala-PAB(m-PEG8)-Exatecan acid-acid Product Name DOTA-NHS Synonyms CAS

Product Name DOTA-NHS Synonyms CAS Number 170908-81-3 Related CAS Molecular Formula C20H31N5O10 Molecular Weight 501

NCCOC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

S)-AHPC-CO-C5-piperazine HCl Synonyms CAS Number n/a Related CAS Molecular Formula C32H50Cl2N6O4S Molecular Weight 685

and radiotherapeutic agents

Azide-Hexanoyl-Val-Ala-PAB(m-PEG8)-Exatecan acid-acid Product Name DOTA-NHS Synonyms CASSOLU KNEX cleavable linker features a Val Ala dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC