DBCO-Hexanoyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan deuterium Product Name Sulfo-CA-SiR Synonyms Sulfo-CA-SiR650

Product Name Sulfo-CA-SiR Synonyms Sulfo-CA-SiR650 CAS Number N/A Related CAS N/A Molecular Formula C40H53ClN3O8SSi Molecular Weight 799

47 SMILES OC(=O)CCOCCOCCOCCNC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Phthalimidinoglutarimide-C4-Br Synonyms Phthalimidinoglutarimide-4'-C4-Br CAS Number n/a Related CAS Molecular Formula C17H19BrN2O3 Molecular Weight 379

The water soluble 6-FAM PEG3 azide has a long PEG3 spacer that separates the dye carboxyfluorescein (commonly known as FAM) from the terminal azide group

DBCO-Hexanoyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan deuterium Product Name Sulfo-CA-SiR Synonyms Sulfo-CA-SiR650SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU