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DBCO-Propionyl-Val-Ala-PAB(m-PEG8)-Exatecan Size:10mg SiR650 Acid CAS Number 1426090-03-0

SKU 60201700967
4.5
USD445.00 USD474.00

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Description

SiR650 Acid CAS Number 1426090-03-0 Related CAS N/A Molecular Formula C27H28N2O4Si Molecular Weight 472

It has been used as a fluorescent substrate/probe to study the distribution and mechanism of action of multidrug resistance-associated protein 2 (Mrp2)

Sulforhodamine B alkyne (Lissamine rhodamine B alkyne) is an excellent azide-reactive fluorescent reagent for labeling azide-containing biological molecules through click chemistry

CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCN)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

DBCO-Propionyl-Val-Ala-PAB(m-PEG8)-Exatecan Size:10mg SiR650 Acid CAS Number 1426090-03-0SOLU KNEX cleavable linker features a Val Ala dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC

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