Mal-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB dbco-hexanoyl gov/ct2/show/NCT04191499 (accessed Mar 29

gov/ct2/show/NCT04191499 (accessed Mar 29

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Product Name Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C68H91FN10O20 Molecular Weight 1387

517 SMILES O=C1N(CC2=C1C=CC=C2NC1=NC(NC2=CC3=C(CCC3)C=C2)=NC=C1)C1CCC(=O)NC1=O Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

Mal-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB dbco-hexanoyl gov/ct2/show/NCT04191499 (accessed Mar 29SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine (PSAR), to enhance aqueous solubility. Solubility and physicochemical properties can be finely tuned