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Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE exatecan Product Name DOTA-tris(t-Bu)ester-C5-propanamido-maleimide Synonyms CAS

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Description

Product Name DOTA-tris(t-Bu)ester-C5-propanamido-maleimide Synonyms CAS Number n/a Related CAS Molecular Formula C40H69N7O10 Molecular Weight 808

Product Name Thalidomide-O-acetamido-PEG5-C2-acid Synonyms Thalidomide-4'-O-acetamido-PEG5-C2-acid CAS Number n/a Related CAS Molecular Formula C28H37N3O13 Molecular Weight 623

9 SMILES ClCCOCCOCCOCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name CP-SS-SulfoCy3 Synonyms SNAP2-SS-SulfoCynine 3 CAS Number Related CAS Molecular Formula C47H56ClN7O9S4 Molecular Weight 1026

Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE exatecan Product Name DOTA-tris(t-Bu)ester-C5-propanamido-maleimide Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is

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