Mal-Propionyl-PEG6-Gly-Gly-Phe-Gly-PAB(m-PEG4)-PNP chemical Isoindole-

Isoindole-

and the commercial tetramethylrhodamine maleimides and iodoacetamides often have lower purities than other tetramethylrhodamine labeling reagents (such as TAMRA SE reagents) due to their synthetic difficulties

Product Name DBCO-Propionyl-Val-Cit-PAB(m-PEG8)-PNP Synonyms CAS Number Related CAS Molecular Formula C65H85N9O20 Molecular Weight 1312

12 Purity (HPLC) >= 95% Physical Appearance Off white Solid Optical Properties Abs/Em Maxima: 494/526 nm Solubility DMSO

Mal-Propionyl-PEG6-Gly-Gly-Phe-Gly-PAB(m-PEG4)-PNP chemical Isoindole-SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an