Mal-Propionyl-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB Size:50mg 22 SMILES [H]C(=O)C1=CC(OC)=C(OC([2H])([2H])[2H])C(OC)=C1 Purity (HPLC)

22 SMILES [H]C(=O)C1=CC(OC)=C(OC([2H])([2H])[2H])C(OC)=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

6-tetrahydro-[1

84 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCO)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Journal of Medicinal Chemistry 2022

Mal-Propionyl-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB Size:50mg 22 SMILES [H]C(=O)C1=CC(OC)=C(OC([2H])([2H])[2H])C(OC)=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or