Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg Product Name SiR-Maleimide Synonyms 6-SiR-Maleimide

Product Name SiR-Maleimide Synonyms 6-SiR-Maleimide CAS Number 2296718-56-2 Related CAS N/A Molecular Formula C33H34N4O5Si Molecular Weight 594

81 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCC#C)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

447 SMILES OC1=CC2=C(C=C1)C1(OC(=O)C3=CC=C(C=C13)C(=O)NCCN1C(=O)C=CC1=O)C1=CC=C(O)C=C1O2 Purity (HPLC) 98% Shipping Conditions Room Temperature Storage Conditions Refrigerated Regulatory Statemen: For Research Use Only

Product Name Thalidomide-5'-piperazine HCl Synonyms CAS Number 2228029-82-9 Related CAS Molecular Formula C17H19ClN4O4 Molecular Weight 378

Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg Product Name SiR-Maleimide Synonyms 6-SiR-MaleimideSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I