Thalidomide-O-PEG1-C2-Br Size:50mg 98 SMILES: CC1(C)\C(=C/C=C/C2=[N+](CCCCCC(=O)NCCN3C(=O)C=CC3=O)C3=CC=C(C=C3C2(C)C)S(O)(=O)=O)N(CCCS([O-])(=O)=O)C2=CC=C(C=C12)S(O)(=O)=O Purity (HPLC):

98 SMILES: CC1(C)\C(=C/C=C/C2=[N+](CCCCCC(=O)NCCN3C(=O)C=CC3=O)C3=CC=C(C=C3C2(C)C)S(O)(=O)=O)N(CCCS([O-])(=O)=O)C2=CC=C(C=C12)S(O)(=O)=O Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

NC1CCN(CC1)C1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

458 SMILES [N-]=[N+]=NCCOCCOCCOCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

18 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCCl)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Thalidomide-O-PEG1-C2-Br Size:50mg 98 SMILES: CC1(C)\C(=C/C=C/C2=[N+](CCCCCC(=O)NCCN3C(=O)C=CC3=O)C3=CC=C(C=C3C2(C)C)S(O)(=O)=O)N(CCCS([O-])(=O)=O)C2=CC=C(C=C12)S(O)(=O)=O Purity (HPLC):Degrader building block for targeted protein degradation. Contains an E3 ligase ligand with a linker and a function group, which can be conjugated to target protein ligands through straightforward chemical reactions. Product Name Thalidomide O PEG1 C2 Br Synonyms Thalidomide 4' O PEG1 C2 Br CAS Number n a Related CAS Molecular Formula C17H17BrN2O6 Molecular Weight 425. 235 SMILES BrCCOCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95%