Azide-Lys(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Size:10mg 556 SMILES CC[C@H](CO)CC1=NC(NCC2=CC=C(C=C2)C2=CC=CC=N2)=C2N=CN(C(C)C)C2=N1 Purity (HPLC)

556 SMILES CC[C@H](CO)CC1=NC(NCC2=CC=C(C=C2)C2=CC=CC=N2)=C2N=CN(C(C)C)C2=N1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

566 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCCC#C)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

324 SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)C2=C(NCCC#C)C=CC=C12 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

and exhibits excellent phot stability

Azide-Lys(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Size:10mg 556 SMILES CC[C@H](CO)CC1=NC(NCC2=CC=C(C=C2)C2=CC=CC=N2)=C2N=CN(C(C)C)C2=N1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Azide Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase