Mal-Propionyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-Exatecan Size:10mg Product Name Phthalimidinoglutarimide-C3-Br Synonyms Phthalimidinoglutarimide-4'-C3-Br

Product Name Phthalimidinoglutarimide-C3-Br Synonyms Phthalimidinoglutarimide-4'-C3-Br CAS Number n/a Related CAS Molecular Formula C16H17BrN2O3 Molecular Weight 365

417 SMILES OC(=O)CCOCCOCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

NCCCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

894 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCCO)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-Exatecan Size:10mg Product Name Phthalimidinoglutarimide-C3-Br Synonyms Phthalimidinoglutarimide-4'-C3-BrSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,