DBCO-Hexanoyl-Val-Cit-PAB(m-PEG8)-Exatecan Size:25mg 1038/s41586-020-2760-4

1038/s41586-020-2760-4

527 SMILES [N-]=[N+]=NCCOCCOCCOCCOCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name: Lissamine rhodamine B C2 maleimide Synonyms: Sulforhodamine B C2 maleimide CAS Number: 1800246-48-3 Molecular Formula: C33H36N4O8S2 Molecular Weight: 680

91 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCC(O)=O)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

DBCO-Hexanoyl-Val-Cit-PAB(m-PEG8)-Exatecan Size:25mg 1038/s41586-020-2760-4SOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC