CC-122 Biotin 385 SMILES: OC1=CC2=C(C=C1)C1(OC(=O)C3=CC=C(C=C13)C(=O)NCC#C)C1=CC=C(O)C=C1O2 Purity (HPLC):

385 SMILES: OC1=CC2=C(C=C1)C1(OC(=O)C3=CC=C(C=C13)C(=O)NCC#C)C1=CC=C(O)C=C1O2 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

665 SMILES OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Targeted protein degraders crowd into the clinic

CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia

CC-122 Biotin 385 SMILES: OC1=CC2=C(C=C1)C1(OC(=O)C3=CC=C(C=C13)C(=O)NCC#C)C1=CC=C(O)C=C1O2 Purity (HPLC):Avadomide (CC 122) is an orally active cereblon modulator. It promotes degradation of Aiolos and Ikaros proteins. Product Name CC 122 Synonyms Avadomide CAS Number 1015474 32 4 Related CAS Molecular Formula C14H14N4O3 Molecular Weight 286. 291 SMILES CC1=NC2=CC=CC(N)=C2C(=O)N1C1CCC(=O)NC1=O Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO, DMF Shipping Conditions Room Temperature Storage Conditions Refrigerated Shelf Life 12 months