Mal-Propionyl-PEG8-Gly-Gly-Phe-Gly-PAB(m-PEG4) dbco-propionyl AggFluor P1 exhibits fluorescence in

AggFluor P1 exhibits fluorescence in both misfolded oligomers and insoluble aggregates but cannot differentiate between these species

Product Name DBCO-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG4)-PNP Synonyms CAS Number Related CAS Molecular Formula C71H86N10O22 Molecular Weight 1431

this product contains a PEG4 linker instead of PEG2

7'-dichlorofluorescein is a fluorescent intracellular pH indicator in the pH 4-5 range

Mal-Propionyl-PEG8-Gly-Gly-Phe-Gly-PAB(m-PEG4) dbco-propionyl AggFluor P1 exhibits fluorescence inSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker